Baseline tissue Doppler imaging-derived echocardiographic parameters and left ventricle reverse remodelling following cardiac resynchronization therapy introduction

INTRODUCTION The aim of the study was to assess the relation of baseline mechanical dyssynchrony with the left ventricular end-systolic volume (LVESV) decrease following cardiac resynchronization (CRT) therapy introduction. MATERIAL AND METHODS Sixty consecutive patients (aged 66.3 ± 8.7 years; 57 men) with chronic heart failure (71.7% of ischaemic and 28.3% of non-ischaemic origin) and current indications for CRT were assessed before and 3 months after biventricular heart stimulator implantation. Longitudinal movements of twelve segments of the left ventricle (LV) (6 basal and 6 midlevel) and two segments of the right ventricle (RV) were analysed using tissue Doppler imaging (TDI) techniques with time from onset of Q wave in ECG to peak systolic velocity in colour-coded TDI (T(TDI)), time to peak strain (T(strain)) and time to peak strain rate (T(strain) (rate)). Minimal and maximal time differences within LV and between LV and RV walls were calculated. RESULTS In the study group LVEF and 6-min walk test distance increased, while NYHA class, NT-proBNP level, left ventricular end-diastolic volume and LVESV decreased. Significant correlations between the magnitude of LVESV reduction with maximal time differences between T(strain) of 12 LV segments (r=0.34, p = 0.017) and time differences between T(TDI) basal LV-RV segments (r = -0.29, p=0.041) were found. CONCLUSIONS Only a few TDI-derived parameters such as maximal time differences between T(strain) of 12 LV segments and T(TDI) difference of LV-RV basal segments can be useful to predict the magnitude of left ventricle reverse remodelling after CRT introduction.